Full Cast List ▾
Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Elena Franklin
Shane Detorre
Bill Murray
Frank Detorre
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Kid Rock
Kidney Rock (voice)
Molly Shannon
Mrs. Boyd
Chris Elliott
Bob
Jonathan Adams
Officer Tom (voice)
Carlos Alazraqui
Spanish Germ (voice)
🎬
Keith Anthony
Additional Character Voices (voice)
Eddie Barth
Conductor (voice)
Sally Brooks
Additional Character Voices (voice)
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
🎬
Michael Carven
Additional Character Voices (voice)
🎬
Paul Christie
Dan Matter / Germ (voice)
Janis Dardaris
Additional Character Voices (voice)
🎬
Wendy Dillon
Additional Character Voices (voice)
Antonio Fargas
Chill the Flu Shot (voice)
🎬
Eddie Frierson
Frank Police Department Officer (voice)
Donald Fullilove
Doughnut (voice)
Jackie Gonneau
Additional Character Voices (voice)
🎬
Shannon Gregory
Additional Character Voices (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Rif Hutton
Charlie (voice)
🎬
Art Kimbro
Additional Character Voices (voice)
🎬
Joyce Kurtz
Additional Character Voices (voice)
Anne Lockhart
Female Red Blood Cell (voice)
Sherry Lynn
Trudy (voice)
Danny Mann
Musician Cell (voice)
Mickie McGowan
Brain Librarian (voice)
🎬
Kenny Olson
Kidney Rock Band (voice)
🎬
Jason Krause
Kidney Rock Band (voice)
